DNA Alkyltransferase By O6 Benzylguanine Analogs Biology Essay.

O6-benzylguanine-mediated enhancement of chemotherapy. Friedman HS(1), Keir S, Pegg AE, Houghton PJ, Colvin OM, Moschel RC, Bigner DD, Dolan ME. Author information: (1)Departments of Surgery, Pathology and Medicine, Duke University Medical Center, Room 047, Baker House, Trent Drive, Durham, North Carolina 27710, USA.

O 6-Benzylguanine (O6-BG) is a synthetic derivative of guanine. It is an antineoplastic agent. It exerts its effect by acting as a suicide inhibitor of the enzyme O6-alkylguanine-DNA alkyltransferase which leads to interruption of DNA repair.

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Synthesis and preliminary biological evaluation of radiolabeled O-6-benzylguanine derivatives, new potential PET imaging agents for the DNA repair protein O-6-alkylguanine-DNA alkyltransferase in.

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